To Explore the Mechanism of Hawthorn in the Intervention of Hyperlipidemia Based on the Gene Expression Omnibus and Network Pharmacology

A common clinical treatment for hyperlipidemia in China is hawthorn, a traditional Chinese herb. However, few researches have been done on its active ingredients and their possible mechanisms treating hyperlipidemia. The chemical constituents of hawthorn were obtained from the encyclopedia medicine, bioavailability druglikeness properties each ingredient analyzed using SwissADME targets action predicted SwissTargetPrediction PharmMapper. Then, we used Gene Expression Omnibus-related gene microarray data to mine differentially expressed genes Meanwhile, collected relevant through DrugBank, Online Mendelian Inheritance Man, GeneCards, DisGeNET Therapeutic Target Database. Based this data, component-target-disease pathway protein-protein interaction networks constructed search tool retrieval interacting genes/proteins. Finally, Metascape was systematically analyze intervention total 8 components 312 gathered 343 prospective associated with predicted, 25 which shared hawthorn-related targets. ontology enrichment analysis revealed that mechanism lies regulation lipid metabolism, nutrition level, hormone level cholesterol transport process. Kyoto genomes peroxisome proliferator activated receptor signaling contained majority core Molecular docking verified could bind closely According findings network pharmacology analysis, main intervene are epicatechin, officinalic acid quercetin, mainly pathway.